Solving the Sixth Painleve' Equation: Towards the Classification of all the Critical Behaviours and the Connection Formulae (October 2010)

The critical behavior of a three real parameter class of solutions of the sixth Painlev\'e equation is computed, and parametrized in terms of monodromy data of the associated $2\times 2$ matrix linear Fuchsian system of ODE. The class may contain solutions with poles accumulating at the critical point. The study of this class closes a gap in the description of the transcendents in one to one correspondence with the monodromy data. These transcendents are reviewed in the paper. Some formulas that relate the monodromy data to the critical behaviors of the four real (two complex) parameter class of solutions are missing in the literature, so they are computed here. A computational procedure to write the full expansion of the four and three real parameter class of solutions is proposed.Comment: 53 pages, 2 figure

Poles Distribution of PVI Transcendents close to a Critical Point (summer 2011)

The distribution of the poles of branches of the Painleve' VI transcendents associated to semi-simple Frobenius manifolds is determined close to a critical point. It is shown that the poles accumulate at the critical point, asymptotically along two rays. The example of the Frobenius manifold given by the quantum cohomology of the two-dimensional complex projective space is also considered.Comment: 35 pages, 10 figures; Physica D (2012

Les mouvements catholiques pour la paix à travers les papiers du père Yves de la Brière (s.j.)

International audienceAnalyse des mouvements catholiques institutionnels pour la paix au travers du journal personnel du RP Yves de la Brière, directeur de la revue jésuite "Etudes", durant l'entre-deux-guerres

Distribution maps of twenty-four Mediterranean and European ecologically and economically important forest tree species compiled from historical data collections

Species distribution maps are often lacking for scientific investigation and strategic management planning at international level. Here, we present the range-wide, natural distribution maps of twenty-four Mediterranean and European forest-tree species of key ecological and economic importance in the Mediterranean basin. Data on the geographic distribution of the twenty-four tree species were compiled from over one hundred published sources, making this contribution one of the most extensive resource available from historical data. Dataset can be accessed at: https://doi.org/10.5281/zenodo.822953. Associated metadata can be accessed at: http://www.fao.org/geonetwork/srv/en/metadata.show?id=56996. These data provide key spatial information to further investigate species occurrence-environment relationships, provide a baseline to assess the future impact of climate change, identify marginal populations with specific genetic resources, among other possible applications

Dépenses culture-médias des ménages en France au milieu des années 2000 : une transformation structurelle

L’analyse des dépenses que les ménages français consacrent aux biens et aux services culturels et de communication permet de prendre la mesure des évolutions au cours des années 2000. Si elles ont diminué en 2006 par rapport à 2001 et ne représentent plus que 4 % du budget disponible contre 4,5 % cinq ans plus tôt, la structure des dépenses culture-médias s’est considérablement transformée. La numérisation des biens culturels a amplifié la transition vers une industrie de services. L’analyse confirme l’influence de l’âge, du niveau d’études, de la catégorie socioprofessionnelle et de la taille de la commune de résidence dans la part des dépenses qu’un ménage français consacre aux dépenses culturelles. Une approche typologique des dépenses identifie trois univers de consommation culturelle : la culture « traditionnelle », la culture de l’écran et la culture « jeune »

Activity Monitoring of Functional OprM Using a Biomimetic Microfluidic Device

International audienceThis paper describes the fabrication and use of a biomimetic microfluidic device for the monitoring of a functional porin reconstituted within miniaturized suspended artificial bilayer lipid membrane (BLM). Such a microfluidic device allows for 1) fluidic and electrical access to both sides of the BLM, 2) reproducible membrane protein insertion and long-term electrical monitoring of its conductance (Gi), thanks to the miniaturization of the BLM. We demonstrate here for the first time the feasibility to insert a large trans-membrane protein through its β-barrel, and monitor its functional activity during more than 1 hour (limited by buffer evaporation). In this paper, we specifically used our device for the monitoring of OprM, a bacterial efflux channel involved in the multidrug resistance of the bacteria Pseudomonas aeruginosa. Sub-steps of the OprM channel conductance were detected during the electrical recordings within our device, which might be due to oscillations between several structural conformations (sub-states) adopted by the protein, as part of its opening mechanism. This work is a first step towards the establishing of a genuine platform dedicated to the investigation of bacterial proteins under reconstituted conditions, a very promising tool for the screening of new inhibitors against bacterial channels involved in drug resistance

Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets

<p>Abstract</p> <p>Background</p> <p>Myostatin (MSTN), a member of the TGF-β superfamily, has been identified as a negative regulator of skeletal muscle mass. Inactivating mutations in the MSTN gene are responsible for the development of a hypermuscular phenotype. In this study, we performed transcriptomic and proteomic analyses to detect altered expression/abundance of genes and proteins. These differentially expressed genes and proteins may represent new molecular targets of MSTN and could be involved in the regulation of skeletal muscle mass.</p> <p>Results</p> <p>Transcriptomic analysis of the Quadriceps muscles of 5-week-old <it>MSTN</it>-null mice (n = 4) and their controls (n = 4) was carried out using microarray (human and murine oligonucleotide sequences) of 6,473 genes expressed in muscle. Proteomic profiles were analysed using two-dimensional gel electrophoresis coupled with mass spectrometry. Comparison of the transcriptomic profiles revealed 192 up- and 245 down- regulated genes. Genes involved in the PI3K pathway, insulin/IGF pathway, carbohydrate metabolism and apoptosis regulation were up-regulated. Genes belonging to canonical Wnt, calcium signalling pathways and cytokine-receptor cytokine interaction were down-regulated. Comparison of the protein profiles revealed 20 up- and 18 down-regulated proteins spots. Knockout of the MSTN gene was associated with up-regulation of proteins involved in glycolytic shift of the muscles and down-regulation of proteins involved in oxidative energy metabolism. In addition, an increased abundance of survival/anti-apoptotic factors were observed.</p> <p>Conclusion</p> <p>All together, these results showed a differential expression of genes and proteins related to the muscle energy metabolism and cell survival/anti-apoptotic pathway (e.g. DJ-1, PINK1, 14-3-3ε protein, TCTP/GSK-3β). They revealed the PI3K and apoptotic pathways as MSTN targets and are in favour of a role of MSTN as a modulator of cell survival in vivo.</p